Intracellular Loop of the Gastrin-Releasing Peptide Receptor for Phospholipase C Activation, Internalization and Chronic Down-regulation
نویسندگان
چکیده
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (M.S., T.N., S.A.M., K.T., R.V.B., R.T.J.); Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.J.V.); Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana (S.J.H.)
منابع مشابه
Importance of amino acids of the central portion of the second intracellular loop of the gastrin-releasing Peptide receptor for phospholipase C activation, internalization, and chronic down-regulation.
Little is known about the function of the central portion of the second intracellular loop (i2 loop) of peptide receptors in activation of downstream pathways and receptor modulatory processes such as receptor internalization or chronic down-regulation (DR). Recent data suggest a role for i2 loop hydrophobic amino acids in these processes. We used site-directed mutagenesis to address these issu...
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تاریخ انتشار 2003